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Cd8atm1Litt
Targeted Allele Detail
Nomenclature
Symbol: Cd8atm1Litt
Name: CD8 antigen, alpha chain; targeted mutation 1, Dan R Littman
MGI ID: MGI:3584476
Synonyms: E8i N
Gene: Cd8a  Location: Chr6:71373427-71379171 bp, + strand  Genetic Position: Chr6, 32.14 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50624
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTwo DNase I hypersensitive sites which together constitute the E8i enhancer element were replaced with a floxed neomycin resistance cassette. (J:50624)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd8a Mutation:  18 strains or lines available
References
Original:  J:50624 Ellmeier W, et al., Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells. Immunity. 1998 Oct;9(4):485-96
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/15/2020
MGI 6.15
The Jackson Laboratory