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Targeted Allele Detail
Symbol: Waptm1Kuw
Name: whey acidic protein; targeted mutation 1, Kay-Uwe Wagner
MGI ID: MGI:3584430
Gene: Wap  Location: Chr11:6585482-6588637 bp, - strand  Genetic Position: Chr11, 4.61 cM
Germline Transmission:  Earliest citation of germline transmission: J:100003
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first exon and the splicing signal at the first exon-intron junction have been replaced by a loxP-flanked Pgk-neo cassette. No whey acidic protein mRNA or protein is detectable by northern or western blot analysis, respectively, in the mammary glands or milk on day 1 of lactation of dams homozygous for the targeted allele, nor is the protein detected in their secretory alveoli by immunohistochemical analysis. Expression in heterozygous dams does not differ significantly from that in wild-type mothers. (J:100003)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Wap Mutation:  31 strains or lines available
Original:  J:100003 Triplett AA, et al., Expression of the whey acidic protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells. Genesis. 2005 Aug 16;43(1):1-11
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.19
The Jackson Laboratory