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Gt(ROSA)26Sortm1(rtTA2S*M2)Whsu
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1(rtTA2S*M2)Whsu
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Wei Hsu
MGI ID: MGI:3584142
Synonyms: Gt(ROSA)26Sortm1(xstpx-rtTA2S*M2)Whsu, R26STOPrtTA
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(rtTA2S*M2)Whsu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99718
Parent Cell Line:  CSL3 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, Transactivator)
Mutation:    Insertion
 
Mutation detailsA synthetic modified version of the rtTA gene preceded by a loxP flanked STOP sequence was inserted into the Gt(ROSA)26Sor locus. This version of rtTA contains 5 amino acid changes in the TetR moiety (S12G, E19G, A56P, D148E, and H179R) and a synthetic optimized transactivating domain. This rtTA has reduced basal activity and enhanced doxycycline sensitivity compared to wild-type rtTA. (J:99718)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  935 strains or lines available
References
Original:  J:99718 Yu HM, et al., Development of a unique system for spatiotemporal and lineage-specific gene expression in mice. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8615-20
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory