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Targeted Allele Detail
Symbol: Adam22tm1Sag
Name: a disintegrin and metallopeptidase domain 22; targeted mutation 1, Koji Sagane
MGI ID: MGI:3584137
Gene: Adam22  Location: Chr5:8072352-8368160 bp, - strand  Genetic Position: Chr5, 3.39 cM
Uncoordinated movements in Adam22tm1Sag/Adam22tm1Sag mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:99692
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA termination codon and neomycin resistance cassette were inserted into exon 8 in the pro-protein domain. Western blot using antisera to the cytoplasmic domain failed to detect mature protein. (J:99692)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adam22 Mutation:  6 strains or lines available
Original:  J:99692 Sagane K, et al., Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice. BMC Neurosci. 2005 May 6;6(1):33
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory