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Ccne1tm1Jro
Targeted Allele Detail
Nomenclature
Symbol: Ccne1tm1Jro
Name: cyclin E1; targeted mutation 1, James M Roberts
MGI ID: MGI:3584133
Synonyms: ET393A
Gene: Ccne1  Location: Chr7:38097984-38107534 bp, - strand  Genetic Position: Chr7, 25.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99695
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Single point mutation
 
Mutation detailsA floxed neomycin resistance cassette was inserted into intron 10 and sequence in exon 11 encoding amino-acid residue 393 was mutated from Thr to Ala (ACA to GCA) preventing phosphorylation of this residue. Heterozygotes were crossed with carriers of Meox2tm1(cre)Sor, excising the neomycin resistance cassette and leaving the T393A point mutation. (J:99695)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccne1 Mutation:  5 strains or lines available
References
Original:  J:99695 Loeb KR, et al., A mouse model for cyclin E-dependent genetic instability and tumorigenesis. Cancer Cell. 2005 Jul;8(1):35-47
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory