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Targeted Allele Detail
Symbol: Ccne1tm1Jro
Name: cyclin E1; targeted mutation 1, James M Roberts
MGI ID: MGI:3584133
Synonyms: ET393A
Gene: Ccne1  Location: Chr7:38097984-38107534 bp, - strand  Genetic Position: Chr7, 25.35 cM
Germline Transmission:  Earliest citation of germline transmission: J:99695
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Single point mutation
Mutation detailsA floxed neomycin resistance cassette was inserted into intron 10 and sequence in exon 11 encoding amino-acid residue 393 was mutated from Thr to Ala (ACA to GCA) preventing phosphorylation of this residue. Heterozygotes were crossed with carriers of Meox2tm1(cre)Sor, excising the neomycin resistance cassette and leaving the T393A point mutation. (J:99695)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccne1 Mutation:  5 strains or lines available
Original:  J:99695 Loeb KR, et al., A mouse model for cyclin E-dependent genetic instability and tumorigenesis. Cancer Cell. 2005 Jul;8(1):35-47
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory