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Ccne1tm1Jro
Targeted Allele Detail
Nomenclature
Symbol: Ccne1tm1Jro
Name: cyclin E1; targeted mutation 1, James M Roberts
MGI ID: MGI:3584133
Synonyms: ET393A
Gene: Ccne1  Location: Chr7:38097984-38107534 bp, - strand  Genetic Position: Chr7, 25.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99695
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted
Mutation:    Single point mutation
 
Mutation detailsA floxed neomycin resistance cassette was inserted into intron 10 and sequence in exon 11 encoding residue 393 was mutated from T to A (ACA to GCA) preventing phosphorylation of this residue. Heterozygotes were crossed with carriers of Meox2tm1(cre)Sor, excising the neomycin resistance cassette and leaving the T393A point mutation. (J:99695)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccne1 Mutation:  3 strains or lines available
References
Original:  J:99695 Loeb KR, et al., A mouse model for cyclin E-dependent genetic instability and tumorigenesis. Cancer Cell. 2005 Jul;8(1):35-47
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory