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Spry2tm1Ayos
Targeted Allele Detail
Nomenclature
Symbol: Spry2tm1Ayos
Name: sprouty RTK signaling antagonist 2; targeted mutation 1, Akihiko Yoshimura
MGI ID: MGI:3584128
Synonyms: Sprouty2-
Gene: Spry2  Location: Chr14:105891947-105896819 bp, - strand  Genetic Position: Chr14, 56.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99827
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced most of exon 2. RT-PCR failed to detect transcript and protein was absent in Western blot of mutant MEFs. (J:99827)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spry2 Mutation:  19 strains or lines available
References
Original:  J:99827 Taketomi T, et al., Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia. Nat Neurosci. 2005 Jul;8(7):855-7
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory