Rag1^tm1(cre)Thr
Targeted Allele Detail

Summary

• Symbol: Rag1^tm1(cre)Thr
• Name: recombination activating 1; targeted mutation 1, Terence H Rabbitts
• MGI ID: MGI:3584018
• Synonyms: Rag1-cre
• Gene: Rag1 Location: Chr2:101468627-101479846 bp, - strand Genetic Position: Chr2, 53.88 cM
• Alliance: Rag1^tm1(cre)Thr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86869
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Rag1^tm1(cre)Thr expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Rag1 (MGI:97848)

• Mutation details: Cre cDNA was cloned in-frame with the endogenous coding sequence, along with an SV40 pA signal and a neomycin resistance cassette. (J:86869)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Rag1 (mouse) Summary of all recombinase alleles driven by Rag1. Alliance mouse Rag1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rag1 Mutation: 120 strains or lines available

References

• Original: J:86869 McCormack MP, et al., The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development. Mol Cell Biol. 2003 Dec;23(24):9003-13
• All: 34 reference(s)