Gt(ROSA)26Sortm1(HD*103Q)Xwy
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1(HD*103Q)Xwy |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, X William Yang |
MGI ID: |
MGI:3583991 |
Synonyms: |
mhtt-exon1 (103Q), RosaHD |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(HD*103Q)Xwy page
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Allele Type: |
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Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm1(HD*103Q)Xwy expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
HTT (3064) |
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Mutation details: A targeting vector was designed with a loxP-flanked transcriptional STOP sequence immediately upstream of a neuropathogenic polyQ-mutant form of the human Huntingtin protein exon 1 (mhtt-exon1) sequence (containing 103 mixed CAA-CAG repeats, each encoding glutamine), all followed by a polyadenylation sequence. When these mice are bred with animals expressing cre under the control of a promoter of interest, The STOP signal is deleted in tissue of interest allowing conditional expression of mhtt1-exon1.
(J:99759, J:123199)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:99759 Gu X, et al., Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron. 2005 May 5;46(3):433-44 |
All: |
5 reference(s) |
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