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Targeted Allele Detail
Symbol: Myctm1Lbox
Name: myelocytomatosis oncogene; targeted mutation 1, Linda M Boxer
MGI ID: MGI:3583919
Synonyms: IgH-3'E-myc
Gene: Myc  Location: Chr15:61985391-61990374 bp, + strand  Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
Histopathological analysis of lymphomas in Myctm1Lbox/Myctm1Lbox and Myctm1Lbox/Myc+ mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:97900
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe IgH 3' enhancers SH1234 were inserted upstream of the locus. RT-PCR of mutants demonstrated elevated transcript levels in spleenic B-lymphocytes, but normal levels in brain, liver, kidney, lung and thymus. (J:97900)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myc Mutation:  23 strains or lines available
Original:  J:97900 Wang J, et al., Regulatory elements in the immunoglobulin heavy chain gene 3'-enhancers induce c-myc deregulation and lymphomagenesis in murine B cells. J Biol Chem. 2005 Apr 1;280(13):12766-73
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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