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Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Andras Nagy
MGI ID: MGI:3583817
Synonyms: Gt(ROSA)26Sortm1Nagy, Gt(ROSA)26Sortm1(rtTA)Nagy, R26rtTA, Rosa26fs-rtTA, ROSA26-rtTA, ROSA26-rtTA-IRES-EGFP, Rosa-eGFP, Rosa-rtTALSL, rtTAflox
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99607
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, Inducible, Reporter, Transactivator)
Mutation:    Insertion
 
Mutation detailsA targeting vector containing a floxed Pgk-neo-pA cassette and a rtTA-IRES-EGFP-pA cassette was inserted into intron 1 of the locus. Upon cre expression, the floxed neo cassette is removed and the ROSA26 promoter drives expression of rtTA and EGFP. Presence of doxycycline results in the formation of an active transcriptional activator and the activation of the responder transgene. (J:80963, J:99607)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  497 strains or lines available
References
Original:  J:99607 Belteki G, et al., Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res. 2005;33(5):e51
All:  128 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory