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Targeted Allele Detail
Symbol: Ptk2btm1Schl
Name: PTK2 protein tyrosine kinase 2 beta; targeted mutation 1, Joseph Schlessinger
MGI ID: MGI:3583796
Synonyms: Pyk2-, PYK2 KO
Gene: Ptk2b  Location: Chr14:66153257-66281052 bp, - strand  Genetic Position: Chr14, 34.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:99741
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into the 5' portion of the sequence encoding the protein tyrosine kinase domain. Northern and western blot analyses indicate this is a null allele. (J:99741)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptk2b Mutation:  3 strains or lines available
Original:  J:99741 Okigaki M, et al., Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10740-5
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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