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Targeted Allele Detail
Symbol: Ntrk3tm1Ddg
Name: neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 1, David D Ginty
MGI ID: MGI:3583736
Synonyms: TrkCF617A
Gene: Ntrk3  Location: Chr7:78179986-78581034 bp, - strand  Genetic Position: Chr7, 44.01 cM
Germline Transmission:  Earliest citation of germline transmission: J:99603
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Not Specified)
Mutation:    Nucleotide substitutions
Mutation detailsA phenylalanine to alanine substitution mutation at residue 617 (F617A) was introduced via homologous recombination using a mutagenized construct with an FRT flanked neomycin resistance tag. Heterozygotes were bred with mice bearing Tg(ACTFLPe)9205Dym which expressed FLP1 recombinase. The resulting allele has the F617A mutation but the neomycin resistance cassette has been excised. (J:99603)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntrk3 Mutation:  9 strains or lines available
Original:  J:99603 Chen X, et al., A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005 Apr 7;46(1):13-21
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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