Ntrk1^tm1Ddg
Targeted Allele Detail

Summary

• Symbol: Ntrk1^tm1Ddg
• Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1, David D Ginty
• MGI ID: MGI:3583733
• Synonyms: TrkA^F592A
• Gene: Ntrk1 Location: Chr3:87685551-87702469 bp, - strand Genetic Position: Chr3, 38.62 cM
• Alliance: Ntrk1^tm1Ddg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99603
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A phenylalanine to alanine substitution mutation at residue 592 (F592A) was introduced via homologous recombination using a mutagenized construct with an FRT flanked neomycin resistance tag. Heterozygotes were bred with mice bearing Tg(ACTFLPe)9205Dym which expressed FLP1 recombinase. The resulting allele has the F592A mutation but the neomycin resistance cassete has been excised. (J:99603)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntrk1 Mutation: 60 strains or lines available

References

• Original: J:99603 Chen X, et al., A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005 Apr 7;46(1):13-21
• All: 25 reference(s)