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Gsdmetm1Ant
Targeted Allele Detail
Nomenclature
Symbol: Gsdmetm1Ant
Name: gasdermin E; targeted mutation 1, University of Antwerp
MGI ID: MGI:3583715
Gene: Gsdme  Location: Chr6:50207401-50263857 bp, - strand  Genetic Position: Chr6, 24.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99624
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA hygromycin resistance cassette flanked by loxP sites replaced exon 8 via homologous recombination. An additional loxP site was inserted between exons 6 and 7. Without cre recombinase exposure this allele was found by RT-PCR to produce appropriately aberrant transcript and western blot analysis failed to detect the protein in homozygotes. (J:99624)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gsdme Mutation:  1 strain or line available
References
Original:  J:99624 Van Laer L, et al., Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells. Neurobiol Dis. 2005 Aug;19(3):386-99
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory