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Ms4a2tm1Chr
Targeted Allele Detail
Nomenclature
Symbol: Ms4a2tm1Chr
Name: membrane-spanning 4-domains, subfamily A, member 2; targeted mutation 1, Chisei Ra
MGI ID: MGI:3583705
Synonyms: FcRB(-), FcRbeta(-)
Gene: Ms4a2  Location: Chr19:11615523-11623719 bp, - strand  Genetic Position: Chr19, 8.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53106
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 1, which includes the translation initiation codon and splice donor site, via homologous recombination. Northern blot and western blot analyses failed to detect signal in homozygotes indicating a null allele. (J:53106)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ms4a2 Mutation:  7 strains or lines available
References
Original:  J:53106 Hiraoka S, et al., Fc receptor beta subunit is required for full activation of mast cells through Fc receptor engagement. Int Immunol. 1999 Feb;11(2):199-207
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory