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Targeted Allele Detail
Symbol: Rec8tm1Mjm
Name: REC8 meiotic recombination protein; targeted mutation 1, Michael J McKay
MGI ID: MGI:3583574
Synonyms: Rec8-
Gene: Rec8  Location: Chr14:55618037-55625395 bp, + strand  Genetic Position: Chr14, 28.19 cM
Germline Transmission:  Earliest citation of germline transmission: J:99402
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting construct was designed to replace 19 coding exons with a loxP-flanked cassette containing GFP and a neomycin resistance cassette. Testes from mutants were demonstrated to lack mRNA by Northern blot analysis. (J:99402)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rec8 Mutation:  18 strains or lines available
Original:  J:99402 Xu H, et al., Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis. Dev Cell. 2005 Jun;8(6):949-61
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory