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Targeted Allele Detail
Symbol: Krastm1Bbd
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1, Mariano Barbacid
MGI ID: MGI:3582830
Synonyms: KrasG12V, KrasLSL, K-rasLSLG12Vgeo, KrasLSLG12Vgeo, K-rasV12, KV12
Gene: Kras  Location: Chr6:145216699-145250239 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Germline Transmission:  Earliest citation of germline transmission: J:86101
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted
Mutation:    Insertion
Mutation detailsIn one homologous recombination event an IRES Beta-geo cassette was inserted into the 3' untranslated region and in a second homologous recombination event a mutation changing codon 12 in exon 1 into a valine was inserted along with a floxed transcriptional stop and PGK-Hydro cassette. This resulted in bicistronic Cre recombination-dependent expression of the oncogenic Kras allele and Beta-geo. (J:86101)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Kras Mutation:  36 strains or lines available
Original:  J:86101 Guerra C, et al., Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell. 2003 Aug;4(2):111-20
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory