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Targeted Allele Detail
Symbol: Pou4f2tm1Rsd
Name: POU domain, class 4, transcription factor 2; targeted mutation 1, Michael G Rosenfeld
MGI ID: MGI:3582493
Synonyms: Brn3.2-
Gene: Pou4f2  Location: Chr8:78433010-78436645 bp, - strand  Genetic Position: Chr8, 36.99 cM, cytoband F1-F5
Germline Transmission:  Earliest citation of germline transmission: J:33502
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
Mutation detailsA neomycin selection cassette replaced a 2.7 kb genomic fragment containing the entire coding sequence of the gene. Immunohistochemical analysis on sections of newborn dorsal root ganglia of homozygous mice confirmed that no detectable protein was expressed from this allele. (J:33502)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou4f2 Mutation:  4 strains or lines available
Original:  J:33502 Erkman L, et al., Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature. 1996 Jun 13;381(6583):603-6
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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