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Arhgef1tm1Kdf
Targeted Allele Detail
Nomenclature
Symbol: Arhgef1tm1Kdf
Name: Rho guanine nucleotide exchange factor (GEF) 1; targeted mutation 1, Klaus-Dieter Fischer
MGI ID: MGI:3582489
Synonyms: Lsc-
Gene: Arhgef1  Location: Chr7:24902912-24926594 bp, + strand  Genetic Position: Chr7, 13.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99463
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin cassette replaced bp 1513-1651 including exon sequences of the DH domain encoding for amino acid residues 476-521. Immunoblot analysis of total spleen cell lysates revealed that homozygous mutants do not express protein. (J:99463)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgef1 Mutation:  43 strains or lines available
References
Original:  J:99463 Girkontaite I, et al., Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses. Nat Immunol. 2001 Sep;2(9):855-62
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory