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Gnastm4Lsw
Targeted Allele Detail
Nomenclature
Symbol: Gnastm4Lsw
Name: GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus; targeted mutation 4, Lee S Weinstein
MGI ID: MGI:3582306
Synonyms: E1-, Gsa
Gene: Gnas  Location: Chr2:174284320-174346744 bp, + strand  Genetic Position: Chr2, 97.89 cM, cytoband E1-H3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99237
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 1 was deleted by crossing Gnastm5Lsw with mice expressing Tg(EIIa-cre)C5379Lmgd in the germline. (J:99237)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnas Mutation:  24 strains or lines available
References
Original:  J:99237 Chen M, et al., Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7386-91
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory