Spsb2^tm1Nch
Targeted Allele Detail

Summary

• Symbol: Spsb2^tm1Nch
• Name: splA/ryanodine receptor domain and SOCS box containing 2; targeted mutation 1, S E Nicholson
• MGI ID: MGI:3582298
• Synonyms: SSB-2^-
• Gene: Spsb2 Location: Chr6:124785640-124787582 bp, + strand Genetic Position: Chr6, 59.17 cM
• Alliance: Spsb2^tm1Nch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99226
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene coding region was deleted by homologus recombination. A beta-galactosidase gene was placed under control of the endogenous promoter. Successful recombination was confirmed by Southern blot analysis. Western blot analysis confirmed the absence of protein in adult mouse tissues. (J:99226)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spsb2 Mutation: 16 strains or lines available

References

• Original: J:99226 Masters SL, et al., Genetic Deletion of Murine SPRY Domain-Containing SOCS Box Protein 2 (SSB-2) Results in Very Mild Thrombocytopenia. Mol Cell Biol. 2005 Jul;25(13):5639-47
• All: 3 reference(s)