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Klf7tm1Rmz
Targeted Allele Detail
Nomenclature
Symbol: Klf7tm1Rmz
Name: Kruppel-like factor 7 (ubiquitous); targeted mutation 1, Francesco Ramirez
MGI ID: MGI:3581890
Synonyms: DeltaK7-neo, Klf7-
Gene: Klf7  Location: Chr1:64029447-64122282 bp, - strand  Genetic Position: Chr1, 32.31 cM, cytoband C1-C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99181
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed PGK-neo cassette replaced part of the 5'UTR and all of exon 1 by homologous recombination. In situ hybridization of mutant E13.5 spinal cord and P1 brain confirmed absence of transcript. Northern blot, RT-PCR and 5' RACE analyses further confirmed absence of transcript. (J:99181)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Klf7 Mutation:  7 strains or lines available
References
Original:  J:99181 Laub F, et al., Transcription Factor KLF7 Is Important for Neuronal Morphogenesis in Selected Regions of the Nervous System. Mol Cell Biol. 2005 Jul;25(13):5699-711
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory