Smad9^tm1.1Mwst
Targeted Allele Detail

Summary

• Symbol: Smad9^tm1.1Mwst
• Name: SMAD family member 9; targeted mutation 1.1, Michael Weinstein
• MGI ID: MGI:3581767
• Synonyms: Smad8^deltaexon3
• Gene: Smad9 Location: Chr3:54663003-54708678 bp, + strand Genetic Position: Chr3, 25.62 cM, cytoband D
• Alliance: Smad9^tm1.1Mwst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99098
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Crossing Smad9^tm1Mwst with Tg(EIIa-cre)C5379Lmgd mice resulted in the removal of exon 3 and the neo cassette. RT-PCR demonstrated the complete deletion of exon 3 in mutants. The deletion putatively results in the deletion of part of the linker and one-third of the MH2 domain of Smad9. (J:99098)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad9 Mutation: 32 strains or lines available

References

• Original: J:99098 Hester M, et al., Smad1 and Smad8 function similarly in mammalian central nervous system development. Mol Cell Biol. 2005 Jun;25(11):4683-92
• All: 1 reference(s)