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Ril1C57BL/10ScSn
QTL Variant Detail
Nomenclature
QTL variant: Ril1C57BL/10ScSn
Name: radiation-induced leukemia sensitivity 1; C57BL/10ScSn
MGI ID: MGI:3581271
QTL: Ril1  Location: unknown  Genetic Position: Chr2, Syntenic
Variant
origin
Strain of Specimen:  C57BL/10ScSn
Variant
description
Allele Type:    QTL
Inheritance:    Codominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:6610

QTLs associated with susceptibility to radiation-induced leukemia were mapped using a population of (A/J x C57BL/10ScSn)F2 intercross animals. Parental strain C57BL/10ScSn is susceptible to radiation-induced leukemia compared to parental strain A/J. (A/Jx C57BL/10ScSn)F1 hybrids exhibit intermediate susceptibility. C57BL/10ScSn exhibits shorter latency and higher mortality than A/J. (A/J x C57BL/10ScSn)F1 hybrids exhibit longer latency similar to parental A/J but have high mortality similar to C57BL/10ScSn. Female animals appear to be more susceptible to leukemia induction but the difference was not found to be statistically significant.

A major locus for resistance to radiation-induced leukemia mapped to mouse Chromosome 2 near Ly11 (69 cM). This locusis named Ril1 (radiation-induced leukemia sensitivity 1). A/J-derived alleles at Ril1 confer resistance to radiation-induced leukemia with codominant inheritance. The Ril1 locus is thought to be proximal to Ly11.

A locus on mouse Chromosome 4 shows linkage to radiation-induced leukemia susceptibility near Cxv2 (62 cM). This locus is named Ril3 (radiation-induced leukemia sensitivity 2). Ril3 is estimated to be 1-3 cM proximal of Cxv2. F2 animals homozygous or heterozygous for C57BL/10ScSn-derived alleles at Ril3 exhibit increased survival after radiation exposure compared to animals homozygous for A/J-derived alleles at Ril3. Cxv2 is considered a likely candidate gene for Ril3 as Cxv2 expression is greater in susceptible strain A/J compared to resistantstrain C57BL/10ScSn.

A C57BL/10ScSn-derived resistance locus mapped to mouse Chromosome 1 near Pep3 (71 cM). This locus is named Ril2 (radiation-induced leukemia sensitivity 3). C57BL/10ScSn-derived alleles at Ril2 (heterozygous or homozygous) confer increased survival after radiation exposure. Bxv1 (92.3 cM) maps near Ril2 and may be a possible candidate gene.

References
Original:  J:6610 Meruelo D, et al., Genetics of susceptibility for radiation-induced leukemia. Mapping of genes involved to chromosomes 1, 2, and 4, and implications for a viral etiology in the disease. J Exp Med. 1981 Oct 1;154(4):1201-11
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/09/2022
MGI 6.21
The Jackson Laboratory