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QTL Variant Detail
QTL variant: Tlag2C57L/J
Name: T lymphoma attenuation gene 2; C57L/J
MGI ID: MGI:3581260
QTL: Tlag2  Location: unknown  Genetic Position: Chr4, Syntenic
Strain of Specimen:  C57L/J
Allele Type:    QTL
Mutation:    Undefined
    This locus confers susceptibility to MNU-induced lymphomas compared to AKR/J. (J:74369)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
Tlag1 and Tlag2 appear to interact. Animals homozygous for AKR/J-derived alleles at Tlag1 and heterozygous for AKR/J- and C57L/J-derived alleles at Tlag2 exhibit the greatest susceptibility to MNU-induced lymphomas.

Mapping and Phenotype information for this QTL, its variants and associated markers


Tlag2, a gene responsible for MNU-induced lymphoma susceptibility, was mapped to 53 cM on mouse Chromosome 4 in a AKR/J x (AKR/J x C57L/J)F1 backcross and confirmed in F2 and F3 animals. (Animals fixed for AKR/J-derived alleles at Tlag1 on mouse Chromosome 7 were used in the study.) Peak lymphoma susceptibility is associated with marker Pmv19 at 52.7 cM with the C57L/J-derived allele conferring dominant lymphoma susceptibility. Tlag1 and Tlag2 appear to interact. Animals homozygous for AKR-derived alleles at Tlag1 and heterozygous at Tlag2 exhibited the highest incidence of MNU-induced tumors. Several candidate genes mapping near Tlag2 are Cdkn2a, Cdkn2b, Lyr, Pcts, Tie1, Tek, Mycl1, Jun, Lck, Pctr1, Pctr2, and Tal1.

Original:  J:74369 Angel JM, et al., Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4. Mol Carcinog. 2002 Feb;33(2):105-12
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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