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Targeted Allele Detail
Symbol: Wdr55tm1Matn
Name: WD repeat domain 55; targeted mutation 1, Angabin Matin
MGI ID: MGI:3580272
Gene: Wdr55  Location: Chr18:36760239-36763708 bp, + strand  Genetic Position: Chr18, 19.46 cM, cytoband B3
Germline Transmission:  Earliest citation of germline transmission: J:98580
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsTargeting took place in ES cells carrying the cre transgene Tg(Prm-cre)70Og, which expresses Cre recombinase under control of the male-germline specific protamine promoter. The insertion of a floxed neo cassette replaced the 3.7 kb coding region. Cre-mediated excision removed the neo cassette upon transmission from male chimeras. (J:98580)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wdr55 Mutation:  9 strains or lines available
Original:  J:98580 Youngren KK, et al., The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature. 2005 May 19;435(7040):360-4
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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