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Targeted Allele Detail
Symbol: Akt3tm1Hem
Name: thymoma viral proto-oncogene 3; targeted mutation 1, Brian A Hemmings
MGI ID: MGI:3580101
Synonyms: Akt3-, Pkbgamma-
Gene: Akt3  Location: Chr1:177020073-177258203 bp, - strand  Genetic Position: Chr1, 82.66 cM, cytoband H4-H6
Germline Transmission:  Earliest citation of germline transmission: J:98804
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsAn IRES-lacZ-neo cassette was inserted into exon 4. Quantitative RT-PCR and Western blot confirmed absence of transcript and protein in mutant brain samples. (J:98804)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 20 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akt3 Mutation:  9 strains or lines available
Original:  J:98804 Tschopp O, et al., Essential role of protein kinase B{gamma} (PKB{gamma}/Akt3) in postnatal brain development but not in glucose homeostasis. Development. 2005 Jul;132(13):2943-54
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory