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Targeted Allele Detail
Symbol: Prkar1atm1.1Lsk
Name: protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1.1, Lawrence S Kirschner
MGI ID: MGI:3580100
Synonyms: Prkar1a-, Prkar1adelta2
Gene: Prkar1a  Location: Chr11:109649405-109669656 bp, + strand  Genetic Position: Chr11, 72.33 cM
Germline Transmission:  Earliest citation of germline transmission: J:98799
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted between exons 1b and 1c and a floxed neomycin resistance cassette was inserted in intron 2. Mice carrying the floxed neomycin resistance cassette were bred to EIIa-cre mice, resulting in removal of the sequences located between exons 1b and 1c and in intron 2. Western blot showed complete absence of protein in mutant mice. (J:98799)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkar1a Mutation:  11 strains or lines available
Original:  J:98799 Kirschner LS, et al., A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. Cancer Res. 2005 Jun 1;65(11):4506-14
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory