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Prkar1atm1.1Lsk
Targeted Allele Detail
Summary
Symbol: Prkar1atm1.1Lsk
Name: protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1.1, Lawrence S Kirschner
MGI ID: MGI:3580100
Synonyms: Prkar1a-, Prkar1adelta2
Gene: Prkar1a  Location: Chr11:109540231-109560482 bp, + strand  Genetic Position: Chr11, 72.33 cM
Alliance: Prkar1atm1.1Lsk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98799
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted between exons 1b and 1c and a floxed neomycin resistance cassette was inserted in intron 2. Mice carrying the floxed neomycin resistance cassette were bred to EIIa-cre mice, resulting in removal of the sequences located between exons 1b and 1c and in intron 2. Western blot showed complete absence of protein in mutant mice. (J:98799)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Prkar1atm1.1Lsk
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkar1a Mutation:  16 strains or lines available
References
Original:  J:98799 Kirschner LS, et al., A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. Cancer Res. 2005 Jun 1;65(11):4506-14
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/15/2022
MGI 6.22
The Jackson Laboratory