Mtor^tm1Clyn
Targeted Allele Detail

Summary

• Symbol: Mtor^tm1Clyn
• Name: mechanistic target of rapamycin kinase; targeted mutation 1, Christopher Lynch
• MGI ID: MGI:3580054
• Synonyms: FRAP1^TMICLYN, mTOR^flox
• Gene: Mtor Location: Chr4:148533068-148642140 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
• Alliance: Mtor^tm1Clyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162945
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A loxP site was inserted upstream of exon 49 and a floxed neo cassette was inserted downstream of a modified exon 50. A point mutation at amino acid D2338 results in a kinases dead protein. (J:162945)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtor Mutation: 117 strains or lines available

References

• Original: J:162945 Lang CH, et al., Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1283-94
• All: 4 reference(s)