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Itgadtm1Bll
Targeted Allele Detail
Nomenclature
Symbol: Itgadtm1Bll
Name: integrin, alpha D; targeted mutation 1, Christie M Ballantyne
MGI ID: MGI:3579559
Synonyms: CD11d-
Gene: Itgad  Location: Chr7:127773105-127822988 bp, + strand  Genetic Position: Chr7, 70.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90954
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.2 kb genomic fragment containing exons 1 and 2 were replaced with a neomycin selection cassette. Flow cytometry demonstrated the absence of protein expression in splenocytes. (J:90954)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgad Mutation:  47 strains or lines available
References
Original:  J:90954 Wu H, et al., Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004 Jul 1;173(1):297-306
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory