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Targeted Allele Detail
Symbol: Slc9a4tm1Ges
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 4; targeted mutation 1, Gary E Shull
MGI ID: MGI:3579458
Synonyms: NHE4-
Gene: Slc9a4  Location: Chr1:40580081-40630725 bp, + strand  Genetic Position: Chr1, 19.51 cM
Abnormal gastric epithelium in 9 week old Slc9a4tm1Ges/Slc9a4tm1Ges mice

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:98566
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA targeting construct was designed to insert a neomycin resistance into exon 2. Northern blot demonstrated a reduction in the size of the transcript in mutant stomach tissue. Sequence analysis showed that exon 2 and the neo gene had been excised and exon 1 was spliced to exon 3. (J:98566)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc9a4 Mutation:  21 strains or lines available
Original:  J:98566 Gawenis LR, et al., Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger. J Biol Chem. 2005 Apr 1;280(13):12781-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
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