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Id4tm1Fsky
Targeted Allele Detail
Nomenclature
Symbol: Id4tm1Fsky
Name: inhibitor of DNA binding 4; targeted mutation 1, Fred Sablitzky
MGI ID: MGI:3579084
Synonyms: Id4-, Id4/lacZ
Gene: Id4  Location: Chr13:48261228-48266026 bp, + strand  Genetic Position: Chr13, 24.71 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98270
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ-neo cassette replaced sequence encoding HLH domain and most of the C-temrinus of the gene. The cassette was inserted in-frame, allowing the expression of a fusion gene encoding the N-terminal 65 amino acids of Id4 fused to beta-galactosidase. RT-PCR of mutant brain and testis failed to detect mRNA encoding the HLH domain. X-gal staining demonstrated that expression of the fusion gene was similar to expression of the endogenous gene expression (J:98270)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Id4 Mutation:  7 strains or lines available
References
Original:  J:98270 Bedford L, et al., Id4 is required for the correct timing of neural differentiation. Dev Biol. 2005 Apr 15;280(2):386-95
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory