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Bntq16C57BL/6J
QTL Variant Detail
Summary
QTL variant: Bntq16C57BL/6J
Name: bone traits QTL 16; C57BL/6J
MGI ID: MGI:3578974
QTL: Bntq16  Location: unknown  Genetic Position: Chr17, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:95898

Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here.

On mouse Chromosome 17 an interval between 18 cM - 50 cM showed linkage to femur length, femur yield displacement, and body mass index. This locus is named Bntq16 (bone traits QTL 16). Maximum linkage occurred at 18 cM for femur length (LOD=4.6). Previously identified bone QTLs mapping near Bntq16 are Fembrs4 (18 cM) and Tbbmd7 (6.6 cM). A second interval between 50 cM - 57 cM showed linkage to femur stiffness, neck ultimate displacement, and femur yield displacement. This locus is named Bntq17. Maximum linkage occurred at 57 cM for femur yield displacement (LOD=5.1). A previously identified bone QTL mapping near Bntq17 is Feml3 (48 cM).

References
Original:  J:95898 Lang DH, et al., Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res. 2005 Jan;20(1):88-99
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory