Bntq4^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bntq4^C57BL/6J
• Name: bone traits QTL 4; C57BL/6J
• MGI ID: MGI:3578907
• QTL: Bntq4 Location: unknown Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:95898

Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here.

A novel locus on mouse Chromosome 3 from 57 cM - 68 cM showedlinkage to femoral neck shear load and alkaline phosphatase levels. This locus is named Bntq4 (bone traits QTL 4).

References

• Original: J:95898 Lang DH, et al., Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res. 2005 Jan;20(1):88-99
• All: 1 reference(s)