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Jak3tm1Tks
Targeted Allele Detail
Nomenclature
Symbol: Jak3tm1Tks
Name: Janus kinase 3; targeted mutation 1, Takashi Saito
MGI ID: MGI:3578806
Synonyms: Jak3-
Gene: Jak3  Location: Chr8:71676296-71690575 bp, + strand  Genetic Position: Chr8, 34.43 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31231
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details7.8 kb of genomic sequence including the JH regions, kinase-like domain and part of the kinase domain was replaced by the neo. RT-PCR confirmed absence of transcript in mutantbone marrow cells. (J:31231)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jak3 Mutation:  47 strains or lines available
References
Original:  J:31231 Park SY, et al., Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity. 1995 Dec;3(6):771-82
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory