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Tg(Igh-VB1-8/Igh-6m)1Mjsk
Transgene Detail
Nomenclature
Symbol: Tg(Igh-VB1-8/Igh-6m)1Mjsk
Name: transgene insertion 1, Mark J Shlomchik
MGI ID: MGI:3578639
Synonyms: mIg, Tg(Igh-VB1-8/Igh-6)1Mjsk
Transgene: Tg(Igh-VB1-8/Igh-6m)1Mjsk  Location: unknown  
Transgene
origin
Strain of Origin:  NOD/Caj
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Igh-VB1-8/Igh-6m)1Mjsk expresses 1 gene
 
Mutation detailsThe transgene encodes a membrane-bound, but not a secreted, immunoglobulin mu heavy chain. The variable region of the transgene comprises the VDJ moiety from the functionally rearranged Igh gene of the C57BL/6-derived B1-8 hybridoma, containing the V-region segment Vh186.2 and recognizing the hapten (4-hydroxy-3-nitrophenyl)acetyl. This is followed by a J-C intron fragment containing the Igh intronic enhancer and an Igh-6 constant region gene (of haplotype a) from which the exon encoding the secreted form of Igmu and its associated polyadenylation signal have been deleted. (J:55066)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:55066 Chan OT, et al., A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med. 1999 May 17;189(10):1639-48
All:  14 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory