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Abca1tm1.1Jp
Targeted Allele Detail
Nomenclature
Symbol: Abca1tm1.1Jp
Name: ATP-binding cassette, sub-family A (ABC1), member 1; targeted mutation 1.1, John S Parks
MGI ID: MGI:3577725
Synonyms: Abca1-
Gene: Abca1  Location: Chr4:53030787-53159895 bp, - strand  Genetic Position: Chr4, 28.57 cM, cytoband A5-B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98093
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
    Abca1tm1Jp mice were crossed with Tg(EIIa-cre)C5379Lmgd mice to remove exons 45 and 46. (J:98093)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abca1 Mutation:  56 strains or lines available
References
Original:  J:98093 Timmins JM, et al., Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest. 2005 May 2;115(5):1333-1342
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory