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Abca1tm1Jp
Targeted Allele Detail
Nomenclature
Symbol: Abca1tm1Jp
Name: ATP-binding cassette, sub-family A (ABC1), member 1; targeted mutation 1, John S Parks
MGI ID: MGI:3577723
Synonyms: Abca1fl, Abca1flox
Gene: Abca1  Location: Chr4:53030787-53159895 bp, - strand  Genetic Position: Chr4, 28.57 cM, cytoband A5-B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98093
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Floxed/Frt)
Mutation:    Insertion
    LoxP sites were inserted to flank exons 45 and 46, which encode the second nucleotide-binding fold. (J:98093)
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abca1 Mutation:  9 strains or lines available
References
Original:  J:98093 Timmins JM, et al., Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest. 2005 May 2;115(5):1333-1342
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory