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Targeted Allele Detail
Symbol: Lims1tm1.2Chen
Name: LIM and senescent cell antigen-like domains 1; targeted mutation 1.2, Ju Chen
MGI ID: MGI:3577473
Synonyms: PINCH1-
Gene: Lims1  Location: Chr10:58323466-58424691 bp, + strand  Genetic Position: Chr10, 29.31 cM
Germline Transmission:  Earliest citation of germline transmission: J:97635
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsLoxP sites were inserted to flank exon 3 and a neo cassette was inserted into intron 3 flanked by FRT sites. Exon 3 was removed by crossing to mice expressing Cre in the germline, leaving the neo cassette. (J:97635)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lims1 Mutation:  31 strains or lines available
Original:  J:97635 Liang X, et al., PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol. 2005 Apr;25(8):3056-62
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory