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Targeted Allele Detail
Symbol: Polhtm1Crey
Name: polymerase (DNA directed), eta (RAD 30 related); targeted mutation 1, Claude-Agnes Reynaud
MGI ID: MGI:3577345
Synonyms: Polh-
Gene: Polh  Location: Chr17:46172004-46202625 bp, - strand  Genetic Position: Chr17, 22.9 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:98037
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsLoxP sites were introduced to flank exon 4, which contains the DE polymerase motifs conserved in all Y family polymerases. Cre expression mediated excision of exon 4 in ES cells, resulting in the direct splicing of exons 3-5. The out-of-frame junction would introduce a stop codon and therefore a truncated protein of 102 amino acids. (J:98037)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Polh Mutation:  22 strains or lines available
Original:  J:98037 Delbos F, et al., Contribution of DNA polymerase {eta} to immunoglobulin gene hypermutation in the mouse. J Exp Med. 2005 Apr 18;201(8):1191-6
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.07
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