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Rhpn2tm1Ssch
Targeted Allele Detail
Nomenclature
Symbol: Rhpn2tm1Ssch
Name: rhophilin, Rho GTPase binding protein 2; targeted mutation 1, Stephanie Schurmans
MGI ID: MGI:3577068
Synonyms: Rhpn2-
Gene: Rhpn2  Location: Chr7:35334170-35392289 bp, + strand  Genetic Position: Chr7, 21.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97638
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe last 28 nucleotides of exon 7 and about 1 kb of intron 7 were replaced by a neomycin resistance gene. Northern and Western blot of mutants confirmed absence of transcript and protein in brain and kidney samples. (J:97638)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rhpn2 Mutation:  18 strains or lines available
References
Original:  J:97638 Behrends J, et al., Normal thyroid structure and function in rhophilin 2-deficient mice. Mol Cell Biol. 2005 Apr;25(7):2846-52
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory