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Vegfdtm1Mach
Targeted Allele Detail
Nomenclature
Symbol: Vegfdtm1Mach
Name: vascular endothelial growth factor D; targeted mutation 1, Marc G Achen
MGI ID: MGI:3576785
Synonyms: Vegfdlz
Gene: Vegfd  Location: ChrX:164373378-164402650 bp, + strand  Genetic Position: ChrX, 76.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97571
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ-pgk-neo cassette was inserted to replace the signal sequence in exon 1 downstream of the translation start site. Northern blot demonstrated lack of expression in mutant E15.5 lungs. Western block confirmed lack of protein in mutants. (J:97571)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vegfd Mutation:  9 strains or lines available
References
Original:  J:97571 Baldwin ME, et al., Vascular endothelial growth factor D is dispensable for development of the lymphatic system. Mol Cell Biol. 2005 Mar;25(6):2441-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory