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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Andrew P McMahon
MGI ID: MGI:3576373
Synonyms: Gt(ROSA)26Sortm1(smo/YFP)Amc, R26-lsl-SmoM2, R26SmoM2, R26SmoM2, RosaSmoM2 c, SmoM2, SmoM2fl, SmoM2/Yfp, SmoM2-YFPfl, SmoOEX
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:89445
Parent Cell Line:  AV3 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Gt(ROSA)26Sortm1(Smo/EYFP)Amc expresses 1 gene
Mutation detailsA loxP flanked PGK-neo-stop cassette upstream of the Yellow Fluorescent Protein/Smoothened homolog (Drosophila) fusion gene (Smo/EYFP) was inserted into the Gt(ROSA)26Sor locus. The mutant allele consists of a fusion product involving Yellow Fluorescent Protein and the constitutively active W539L point mutation of the mouse smoothened homolog (Drosophila) gene (SmoM2). Expression of the Smo/EYFP fusion gene is blocked by a loxP-flanked STOP fragment placed between the Gt(ROSA)26Sor promoter and the Smo/EYFP sequence. (J:89445)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  290 strains or lines available
Phenotypic Similarity to Human Syndrome: Medullablastoma (J:139574)

Original:  J:89445 Jeong J, et al., Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev. 2004 Apr 15;18(8):937-51
All:  64 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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