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Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Andrew P McMahon
MGI ID: MGI:3576373
Synonyms: Gt(ROSA)26Sortm1(smo/YFP)Amc, R26-lsl-SmoM2, R26SmoM2, R26SmoM2, RosaSmoM2 c, SmoM2, SmoM2fl, SmoM2/Yfp, SmoM2-YFPfl, SmoOEX
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89445
Parent Cell Line:  AV3 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(Smo/EYFP)Amc expresses 1 gene
 
Mutation detailsA loxP flanked PGK-neo-stop cassette upstream of the Yellow Fluorescent Protein (YFP) and mouse gene (SMO/EYFP) was inserted into the locus. The mutant allele consists of a fusion product involving YFP and the constitutively active W539L point mutation of the mouse gene (SmoM2), which corresponds to the W535L mutation in the human sequence. Expression of the fusion gene is blocked by a loxP-flanked STOP fragment placed between the endogenous promoter and the fusion sequence. (J:89445)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  497 strains or lines available
References
Original:  J:89445 Jeong J, et al., Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev. 2004 Apr 15;18(8):937-51
All:  120 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory