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Targeted Allele Detail
Symbol: Pgrtm2(cre)Lyd
Name: progesterone receptor; targeted mutation 2, John P Lydon
MGI ID: MGI:3576366
Synonyms: Pgrcre, PRCre, PR-Cre
Gene: Pgr  Location: Chr9:8899833-8968611 bp, + strand  Genetic Position: Chr9, 2.46 cM
Germline Transmission:  Earliest citation of germline transmission: J:97321
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
Mutation detailsCre recombinase cDNA was inserted into exon 1. An untranslated region was created immediately 5' of the cDNA by mutating the ATG codon for the B isoform to prevent an in-frame fusion from the N-terminal of the cre cDNA to the remaining 120 amino acids at the N-terminal end of the endogenous gene. A loxP-flanked neo was inserted 3' of the cre insertion. RNase protection analysis demonstrated that cre transcription was restricted to progestin target tissues, including the uterus, mammary gland and oviduct/ovary. (J:97321)
 Tissue activity of this recombinase allele
Driver: Pgr     Summary of all recombinase alleles driven by Pgr. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pgr Mutation:  10 strains or lines available
Original:  J:97321 Soyal SM, et al., Cre-mediated recombination in cell lineages that express the progesterone receptor. Genesis. 2005 Feb;41(2):58-66
All:  136 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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