Sh2d1a^tm1Cpt
Targeted Allele Detail

Summary

• Symbol: Sh2d1a^tm1Cpt
• Name: SH2 domain containing 1A; targeted mutation 1, Cox Terhorst
• MGI ID: MGI:3576262
• Synonyms: SAP-, SAPKO, SH2D1A-
• Gene: Sh2d1a Location: ChrX:41591442-41610974 bp, + strand Genetic Position: ChrX, 23.2 cM, cytoband A5
• Alliance: Sh2d1a^tm1Cpt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97756
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exon 1. Absence of transcript was confirmed in mutant spleen and thymus via RT-PCR and absence of protein in mutant thymus was demonstrated by immunoblotting. (J:97756)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2d1a Mutation: 10 strains or lines available

References

• Original: J:97756 Wu C, et al., SAP controls T cell responses to virus and terminal differentiation of TH2 cells. Nat Immunol. 2001 May;2(5):410-4
• All: 21 reference(s)