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Targeted Allele Detail
Symbol: Cyp27b1tm1Hfd
Name: cytochrome P450, family 27, subfamily b, polypeptide 1; targeted mutation 1, Hector F DeLuca
MGI ID: MGI:3576226
Gene: Cyp27b1  Location: Chr10:127048250-127053006 bp, + strand  Genetic Position: Chr10, 74.5 cM
Germline Transmission:  Earliest citation of germline transmission: J:97370
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe majority of the coding region was replaced by lacZ and neomycin resistance genes. Absence of transcript in mutants was confirmed by RT-PCR of total kidney RNA. (J:104572)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp27b1 Mutation:  21 strains or lines available
Original:  J:97370 Healy KD, et al., Parathyroid hormone decreases renal vitamin D receptor expression in vivo. Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4724-8
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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