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Tg(Cd4-TGFBR2)16Flv
Transgene Detail
Nomenclature
Symbol: Tg(Cd4-TGFBR2)16Flv
Name: transgene insertion 16, Richard A Flavell
MGI ID: MGI:3575738
Synonyms: CD4dnTGFbetaRII, CD4dnTgfbr2, CD4-dnTGFBRII, CD4dn-TGF-RII, dnTbetaRII, dnTGFbetaRII, dnTGF-betaRII, dnTgfbr2+
Transgene: Tg(Cd4-TGFBR2)16Flv  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x C3H
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Cd4-TGFBR2)16Flv expresses 1 gene
 
Mutation detailsThis transgene contains the mouse CD4 antigen promoter, sequence encoding the extracellular and transmembrane regions, nucleotides -7 and +573, of the human transforming growth factor, beta receptor II (70/80kDa) and a polyadenylation signal. Transgene expression is detected by RT-PCR analysis of thymus tissue, and is at a level sufficient to block TGF-beta signaling specifically in T cells. (J:97554)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:97554 Gorelik L, et al., Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity. 2000 Feb;12(2):171-81
All:  59 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory