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Drd4tm1(IL2RA)Tao
Targeted Allele Detail
Summary
Symbol: Drd4tm1(IL2RA)Tao
Name: dopamine receptor D4; targeted mutation 1, Toshihiko Aosaki
MGI ID: MGI:3575692
Gene: Drd4  Location: Chr7:140871931-140874868 bp, + strand  Genetic Position: Chr7, 86.6 cM
Alliance: Drd4tm1(IL2RA)Tao page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97412
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert the human IL2RA sequence and a neo into exon 2. The absence of wild-type protein was confirmed by RT-PCR. (J:97412)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd4 Mutation:  31 strains or lines available
References
Original:  J:97412 Shin RM, et al., Dopamine D4 receptor-induced postsynaptic inhibition of GABAergic currents in mouse globus pallidus neurons. J Neurosci. 2003 Dec 17;23(37):11662-72
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory