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Ehmt1tm1Yshk
Targeted Allele Detail
Nomenclature
Symbol: Ehmt1tm1Yshk
Name: euchromatic histone methyltransferase 1; targeted mutation 1, Yoichi Shinkai
MGI ID: MGI:3575505
Synonyms: GLP-
Gene: Ehmt1  Location: Chr2:24789928-24919614 bp, - strand  Genetic Position: Chr2, 16.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97244
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exon 5 and part of exon 6 with a neomycin resistance gene. The deleted sequence encodes the catalytic core region of the SET domain. (J:97244)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ehmt1 Mutation:  66 strains or lines available
References
Original:  J:97244 Tachibana M, et al., Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev. 2005 Apr 1;19(7):815-26
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory